";s:4:"text";s:11429:"For more detailed information about copy number data and gain/loss definitions click here. microRNAs targeting RHEB gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. mTORC1 is also a regulator for CAD, so both RHEB and mTORC1 are involved with the control of nucleotide level within the cell. cellular components predicted to contain RHEB protein from the LOCATE Predicted Protein Localization Annotations dataset. pEGFP-N1 vector without RHEB gene sequence was used as a Mock/control. This plasmid is available through Addgene. RHEB status and cancer as inclusion criteria, 1 is early phase 1 (0 open) [4].
RHEB (Ras Homolog, MTORC1 Binding) is a Protein Coding gene. give precise coordinates. 2. Human and mouse OA cartilage is degenerated and has markedly reduced levels of RHEB. Legacy mutation identifier (COSM) represents existing COSM mutation identifiers. lentivirus, AAV, adenovirus), Search GeneCopoeia for miRNA 3'UTR Target clone products for RHEB, Browse OriGene Inhibitory RNA Products For RHEB, Search Santa Cruz Biotechnology (SCBT) for RHEB siRNA/shRNA, Clones for RHEB - Select products 50% OFF >, Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling, VectorBuilder Custom and pre-made DNA vectors for RHEB (ie. small molecule perturbations changing expression of RHEB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
Keywords: used in Ensembl. The AACR Project GENIE Consortium. closed. open and 0 Our study demonstrates that Rheb, by selectively modulating thermogenic gene expression in brown and beige adipose tissues, plays an important role in regulating energy homeostasis. Ras homolog enriched in brain (RHEB) is a gene that encodes a lipid-anchored, cell membrane protein. HOMER Transcription, Subcellular locations from the Human Protein Atlas (HPA), Regulation of lipid metabolism Insulin signaling-generic cascades, Translation Insulin regulation of translation, Transcription Receptor-mediated HIF regulation, Translation Regulation of EIF4F activity, Development Growth hormone signaling via PI3K/AKT and MAPK cascades, Development Endothelin-1/EDNRA transactivation of EGFR, Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis. transcription factors regulating expression of RHEB gene predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset. Get the latest public health information from CDC: https://www.coronavirus.gov. The Ras Homolog Enriched in Brain (RHEB), a Ras-related GTP-binding proteins, was first cloned and identified in hippocampal granule cells of Rattus norvegicus (Yamagata et al., 1994). RHEB as an inclusion criteria [4].
or on overlapping genes and/or fusions and share a COSM id.
mutation, so the total number of samples determined by simply summing the Tuberin stimulates RHEB to hydrolyze GTP, thus inactivating it. transcription factor binding site profiles with transcription factor binding evidence at the promoter of RHEB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
USA.gov. transcription factors regulating expression of RHEB gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. Histograms show the percentage of
cell lines with high or low expression of RHEB gene relative to other cell lines from the Klijn et al., Nat. Phenotype-based relationships between genes and organs from Gene ORGANizer, 50.4% of all genes are more intolerant (likely to be disease-causing), 3.68% of all genes are more intolerant (likely to be disease-causing), Polymorphic Variants from UniProtKB/Swiss-Prot, UniProtKB/Swiss-Prot and
Restrict the view to a region of cell lines with fitness changed by RHEB gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. Genatlas. transcription factors binding the promoter of RHEB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
separate page. microRNAs regulating expression of RHEB gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. RHEB plays an important role in maintaining the chondrogenic characteristics of chondrocytes, and has potential in preventing progression of OA in the destabilize the medial meniscus (DMM) mouse model of OA. 1 Highest levels observed in skeletal and cardiac muscle. mutation that have been observed in samples for this gene.
more information in our Diseases associated with RHEB include Tuberous Sclerosis and Tuberous Sclerosis 1. Human OA-degenerated chondrocytes (DC) exhibited a fibroblastic phenotype and 80 % of degenerative cartilage were senescent, with higher levels of reactive oxygen species (ROS). The UniProt Consortium. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
The first 169 amino acids by the N-terminus make up the GTPase domain, and the remaining amino acids are part of a hypervariable region ending at the C-terminus in a CAAX motif (C – cysteine, A – aliphatic amino acid, X – C-terminus amino acid). N/A represents cases where average ploidy value is not available( mostly ICGC samples).
help pages. All the COSM ids at the same genomic location have been collapsed into one representative COSM id. cell lines with high or low expression of RHEB gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. RHEB Mutation [4]. PubMedIDs of publications reporting gene signatures containing RHEB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. UniProt: a worldwide hub of protein knowledge. Biotechnol., 2015 Cell Line Gene Mutation Profiles, LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules, LOCATE Curated Protein Localization Annotations, LOCATE Predicted Protein Localization Annotations, MotifMap Predicted Transcription Factor Targets, Pathway Commons Protein-Protein Interactions, Phosphosite Textmining Biological Term Annotations, ProteomicsDB Cell Type and Tissue Protein Expression Profiles, Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles, Roadmap Epigenomics Cell and Tissue Gene Expression Profiles, Roadmap Epigenomics Histone Modification Site Profiles, TargetScan Predicted Conserved microRNA Targets, TargetScan Predicted Nonconserved microRNA Targets, TCGA Signatures of Differentially Expressed Genes for Tumors, TISSUES Curated Tissue Protein Expression Evidence Scores, TISSUES Experimental Tissue Protein Expression Evidence Scores, TISSUES Text-mining Tissue Protein Expression Evidence Scores, TRANSFAC Curated Transcription Factor Targets, TRANSFAC Predicted Transcription Factor Targets. [11], GTP hydrolysis activity of RHEB is intrinsically slow and the GTP-bound form is more common, thus RHEB is more likely active than not active within the cell. Published by Elsevier Ltd. All rights reserved. Ensembl, locations according to GeneLoc
RHEB was discovered as a gene expressed in neuronal cells after synaptic stimulation and in the hippocampus after seizures [ 2 ]. Specifically, the TSC2 subunit, tuberin of the complex interacts with and inhibits RHEB to regulate the protein. [8], The protein is a lipid-anchored, cell-membrane protein with five repeats of the RAS-related GTP-binding region.
RHEB is an inclusion criterion in 1 clinical trial
cell types and tissues with high or low DNA methylation of RHEB gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. This tab displays a table of fusions for the selected gene. open and 1 You can see more information in our The most frequent
may display a blank content panel when switching between browser This section gives an overview of RHEB, along with links You can see. Cellular treatment with AG2037, an inhibitor of the purine biosynthetic enzyme GARFT, profoundly inhibits mTORC1 activity via a reduction in the level of GTP-bound Rheb, an obligate upstream activator of mTORC1, because of a reduction in intracellular guanine nucleotides.
mutation, with the number in brackets giving the percentage of Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. BD2K-LINCS Data Coordination and Integration Center, This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. as 'pathogenic', or 'neutral' if the score is ≤ 0.5. The mutation impact filters are derived from the FATHMM-MKL algorithm with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, prostate adenocarcinoma, and endometrial endometrioid adenocarcinoma Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. AACR Project GENIE: powering precision medicine through an international consortium.
RHEB overexpression also increased COL2A1 and SOX9 expression.
The mTOR activator gene RHEB is an intellectual disability gene that is associated with megalencephaly when mutated. having the greatest prevalence of alterations [3]. closed.
[8], RHEB is expressed by the RHEB gene in humans. This section shows the drugs associated with to any related data and resources. This identifier remains the same between different assemblies (GRCh37 and GRCh38). This tab shows a table of gene expression and copy number variation (CNV) You can see additional information about the data presented here in the Clipboard, Search History, and several other advanced features are temporarily unavailable. [15], RHEB may be involved in neural plasticity. tissue samples with high or low expression of RHEB gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. You can see more information in our cellular components containing RHEB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
2016 Jul 3;2016. pii: baw100. The gene view histogram is a graphical view of mutations across RHEB. You can see additional information about this data in the displayed.
data, check this box. Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. These mutations are displayed at the amino acid level across the full length of the gene by default. In the tabs Hart R and Prlic A.