11, No. �h���4J�"6���F[4��bѶ;/��{t��͡��]���fo�q�{�q�?bM ���&ϫ���9
���b�*ޕ��b*��/��D%�S>G���(�� #�X9�.��l�%�1[����&R�!��K嘷8[A������u�?�4�BK/�d5�M ׃�������Ѹ��ھ*w�#}��-���J��X� 0�&*�h�سhޠ/�8G\K�� �=���Xʿ/61D�U�(\�ד�]��醘� ZTƆ�F{e���{�eS��=��32�1�Z��m � � ~7��y�ޢ�����Gh�&����k�F����_�_~S��@��E�hF>,�=5R��( It has been shown to counteract most of the inhibitory effects of adenosine on neuroexcitability (14,18), neurotransmitter release (34), arousal (35), and spontaneous activity (3). 1986, 3.
Possible mechanisms of central nervous system fatigue during exercise.
6, 1 December 2005 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 37, No. Conclusions: However, whereas anxiety tends to increase heart rate
F1: Chemical structure of caffeine and adenosine.Depicted are the chemical structures of the widely used drug “caffeine” and the endogenously produced nucleoside “adenosine” for comparison. 2, Advances in Physical Education, Vol. When caffeine was administered 5 min before NECA injection (caffeine plus NECA), it blocked the reduction in run time to fatigue that occurred in NECA and was not different from vehicle (63.62 ± 14.98 min,P = 0.397). In fact, caffeine binding to adenosine receptors causes the opposite effect: nerve cell activity speeds up, and brain blood vessels constrict. 3.Effect of intracerebroventricular injection (n = 10) of NECA, vehicle, caffeine, and caffeine + NECA on treadmill run time to fatigue in male rats. 1, 2 April 2011 | European Journal of Applied Physiology, Vol. The number of lines crossed for each group was 72 ± 36, 284 ± 77, 437 ± 51, and 67 ± 54, respectively. Its lipophilic nature enables it to easily cross cell membranes including the BBB (32). 82, No. 50, No. 1, 30 September 2016 | European Journal of Applied Physiology, Vol. 0000009559 00000 n
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