";s:4:"text";s:8858:"Purinergic dysregulation in pulmonary hypertension.
Life Sci. in 1963 Berne and Gerlach et al. A vasodilator with effects confined to the pulmonary circulation would therefore be advantageous in such patients. Invest Ophthalmol Vis Sci. By continuing to browse this site you are agreeing to our use of cookies. Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine. Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction. Takahama H, Asanuma H, Tsukamoto O, Ito S, Kitakaze M. Int J Cardiol Heart Vasc. Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs. In all patients, there was a dose-dependent and significant reduction (mean maximal percent decrease from baseline, 38.9%; p less than 0.001) in PVR mediated through a decrease in pulmonary artery pressure and an increase in cardiac output.
7272 Greenville Ave. 2016 Feb 23;11(2):e0150021. doi: 10.1152/ajpheart.1999.276.6.H1877. Pharmacology of the Adenosine A3 Receptor in the Vasculature and Essential Hypertension.
1997 Sep;273(3 Pt 1):L581-7.
HHS 2000 Jul;91(1):76-81. doi: 10.1097/00000539-200007000-00015. The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Ali S, Metzger WJ, Olanrewaju HA, Mustafa SJ. The nonspecific calcium-activated potassium (K(Ca)) channel blocker tetrabutylammonium attenuated adenosine-induced dilation, as did the intermediate-conductance K(Ca) blocker clotrimazole.
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The roles of A(1) and A(2) receptor subtypes are opposing, with the former being inhibitory to AC-mediated dilator actions of the latter. Human … In conclusion, adenosine endothelium independently dilates HCAs from patients with heart disease through a receptor-mediated mechanism that involves the activation of intermediate-conductance K(Ca) channels via an AC signaling pathway. |
NIH
1994 Sep;270(3):893-9. Davila A, Tian Y, Czikora I, Li J, Su H, Huo Y, Patel V, Robinson V, Kapuku G, Weintraub N, Bagi Z. Circ Heart Fail. 1-800-AHA-USA-1 AIV was mimicked by 10 microM 5'-(N-ethylcarboxamido)adenosine (NECA), a nonselective adenosine agonist. Customer Service Get the latest public health information from CDC: https://www.coronavirus.gov.
Activation of multiple sites by adenosine analogues in the rat isolated aorta. Am J Cardiovasc Drugs. Compr Physiol. This site needs JavaScript to work properly.
eCollection 2016. Adenosine-induced vasodilation was not inhibited by endothelial denudation, but A(2) receptor antagonism with 3,7-dimethyl-1-propargylxanthine and adenylate cyclase (AC) inhibition with SQ22536 significantly attenuated the dilation. eCollection 2020. Am J Physiol Heart Circ Physiol. doi: 10.1161/CIRCHEARTFAILURE.118.005762.
In contrast, NECA-induced vasodilation was not attenuated by the A1 antagonist 8-cyclopentyl-1,3-dipropylxanthine (1 microM).
Sci Rep. 2020 Oct 22;10(1):18078. doi: 10.1038/s41598-020-75224-0. These findings suggest that AIV is mediated via the A2b receptor and that AIV occurs via an NO-independent mechanism. Park KW, Dai HB, Comunale ME, Gopal A, Sellke FW. Adenosine is a key myocardial metabolite that elicits coronary vasodilation in a variety of pathophysiological conditions. | Please enable it to take advantage of the complete set of features! doi: 10.1152/ajpheart.00572.2015. NIH 142, Issue 16_suppl_1, October 20, 2020: Vol. Because adenosine has been implicated as a mediator of hypoxic vasodilation in the systemic circulation and because the concentration of adenosine in the lung has been shown to increase with hypoxia, we tested the hypothesis that adenosine is the mediator of hypoxic pulmonary vasodilation. At 10 microM, a minimal vasodilatory effect was seen with the nonselective adenosine agonists CV-1808 and N6-(2-phenylisopropyl)adenosine (R-PIA) compared with NECA.
USA.gov. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The American Heart Association is qualified 501(c)(3) tax-exempt
Unfortunately, the usefulness of the drugs currently available is limited by accompanying systemic hypotension. In this study, the effect(s) of selective adenosine agonist and antagonist on the hypoxic pressor response (HPR) was assessed in the isolated blood-perfused rat lung. 2005 Jun;46(6):2113-9. doi: 10.1167/iovs.04-1438. Adenosine and ATPγS protect against bacterial pneumonia-induced acute lung injury. Get the latest research from NIH: https://www.nih.gov/coronavirus. Adenosine is a key myocardial metabolite that elicits coronary vasodilation in a variety of pathophysiological conditions. USA.gov. proposed that adenosine mediates local metabolic control of coronary blood flow, whereby coronary flow and myocardial oxygen consumption are kept in balance.The hypothesis is that adenosine released from cardiomyocytes crosses the interstitial space to activate adenosine receptors on coronary vascular smooth muscle cells and cause vasodilation. Because of its pharmacokinetic and vasodilator properties, adenosine may have a specific role in the investigation of primary pulmonary hypertension.
use prohibited. We examined the mechanism of adenosine-induced vasodilation in coronary arterioles from patients with heart disease. The A2 receptor has been suggested to mediate adenosine-induced vasodilation (AIV). COVID-19 is an emerging, rapidly evolving situation. H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation. Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), Journal of the American Heart Association (JAHA), Customer Service and Ordering Information, October 20, 2020: Vol.